When considering a nanomaterial drug delivery system, size of the nanoparticle is the key parameter; it influences uptake, degradation and clearance from the body. Nanoparticles 30 nm to a few hundred nm passively accumulate at the site of tumours due to leaky vasculator, phagocytosis favours particles >500 nm, whilst biliary and renal clearance occurs with particles <30 nm and <8 nm respectively and the liver has a lower uptake of smaller particles (25 and 50 nm) compared to larger particles (200 and 300 nm). Accurate measurement of the particles being administered is therefore imperative.
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